Ibuprofen ม ผลต อ gi bleed น อยส ด

Introduction: Ibuprofen is a non-steroidal anti-inflammatory drug frequently used in children for fever and pain. It is usually considered to be safe and of low risk at low doses and short-term use.

Patients and methods: The aim of our study was to review the cases of gastrointestinal bleeding and assessment of gastrointestinal bleeding after recommended doses of ibuprofen.

Results: We describe 9 previously healthy patients with upper gastrointestinal bleeding after receiving weight-related doses of ibuprofen for fever.

Copyright © 2011 Asociación Española de Pediatría. Published by Elsevier España. All rights reserved.

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Upper Gastrointestinal Bleeding in Children: The Role of Helicobacter pylori Infection and Non-steroidal Anti-inflammatory Drug Use.

In summary, scientific evidence demonstrates that the rate of serious GI adverse events associated with the use of NSAIDs is comparatively low depending on the definition used, serious GI adverse events occur in 1% of patients each year and occurs in the use of high doses with long-term treatment in chronic conditions. At OTC doses, the incidence of GI adverse events in both adults and children receiving ibuprofen has been shown to be similar to that of paracetamol. Even at prescription doses of ibuprofen, upper GI bleeding is infrequent, and is usually associated with long-term use. Of all the NSAIDs, ibuprofen appears to have one of the best GI tolerability profiles.

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Over-the-counter ibuprofen and risk of gastrointestinal bleeding complications: a systematic literature review.